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Journal article

Fibroblast growth factor receptor 2, gain-of-function mutations, and tumourigenesis: investigating a potential link.

Abstract:

Activating germline mutations in the fibroblast growth factor receptor (FGFR) gene family have been identified in several dominantly inherited skeletal disorders; in the case of FGFR3, the same somatically arising mutations have also been isolated from a variety of tumour tissues. Whilst the role of FGFR2 mutations in congenital syndromes has been well documented, their relationship with cancer has not been clearly defined. Based on evidence that gain-of-function mutations in FGFR2 drive posi...

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Publication status:
Published

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Publisher copy:
10.1002/path.1816

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Journal:
Journal of pathology
Volume:
207
Issue:
1
Pages:
27-31
Publication date:
2005-09-01
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
Source identifiers:
119532

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