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Comparison of capillary whole blood, venous whole blood, and plasma concentrations of mefloquine, halofantrine, and desbutyl-halofantrine measured by high-performance liquid chromatography.

Abstract:

Whole blood mefloquine, halofantrine, and desbutyl-halofantrine concentrations were measured by high-performance liquid chromatography in capillary blood, venous blood, and venous plasma samples from patients along the Thai/Burmese border with falciparum malaria who were treated with either mefloquine (25 mg/kg) or halofantrine (24 mg/kg or 72 mg/kg). The limits of detection for mefloquine, halofantrine, and desbutyl-halofantrine were 50, 15, and 10 ng/ml, respectively, with 200 microliters w...

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Publication status:
Published

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Authors


Ter Kuile, FO More by this author
Teja-Isavatharm, P More by this author
Edstein, MD More by this author
Keeratithakul, D More by this author
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Journal:
The American journal of tropical medicine and hygiene
Volume:
51
Issue:
6
Pages:
778-784
Publication date:
1994-12-05
EISSN:
1476-1645
ISSN:
0002-9637
URN:
uuid:9e4b44c7-86da-42a9-9f44-0d30beeb1011
Source identifiers:
31247
Local pid:
pubs:31247

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