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Journal article

Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.

Abstract:

The gene for insulin-degrading enzyme (IDE) represents a strong positional and biological candidate for type 2 diabetes susceptibility. IDE maps to chromosome 10q23.3, a region linked to diabetes in several populations; the rat homolog has been directly implicated in diabetes susceptibility; and known functions of IDE support an important role in glucose homeostasis. We sought evidence for association between IDE variation and diabetes by mutation screening, defining local haplotype structure...

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Publication status:
Published

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Publisher copy:
10.2337/diabetes.52.5.1300

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
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Journal:
Diabetes
Volume:
52
Issue:
5
Pages:
1300-1305
Publication date:
2003-05-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:9e46ed9f-5f35-4d5f-8fa8-94efd1ef917a
Source identifiers:
3982
Local pid:
pubs:3982

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