Out of the box binding determines specificity of SH2 domain interaction.

Journal article

SH2 domains are phosphotyrosine specific interaction modules with largely overlapping sequence specificities. A recent structure by Bae et al. revealed that SH2 domain specificity can be mediated by secondary binding sites located outside the phosphotyrosine binding pocket.

Authors: Müller, S; Knapp, S

• Journal: Structure (London, England : 1993)
• Volume: 17
• Issue: 8
• Pages: 1040-1
• Publication date: 2009-08-12
• ISSN: 1878-4186
• Language: English
• Subjects: metabolism; Protein Binding; Signal Transduction; Binding Sites; chemistry; Phosphotyrosine; genetics; src Homology Domains; Mutation