Journal article icon

Journal article

Chromatin organization is a major influence on regional mutation rates in human cancer cells.

Abstract:

Cancer genome sequencing provides the first direct information on how mutation rates vary across the human genome in somatic cells. Testing diverse genetic and epigenetic features, here we show that mutation rates in cancer genomes are strikingly related to chromatin organization. Indeed, at the megabase scale, a single feature—levels of the heterochromatin-associated histone modification H3K9me3—can account for more than 40% of mutation-rate variation, and a combination of features can accou...

Expand abstract

Actions


Access Document


Publisher copy:
10.1038/nature11273

Authors


Schuster-Böckler, B More by this author
Journal:
Nature
Volume:
488
Issue:
7412
Pages:
504-507
Publication date:
2012-08-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:9e437598-889c-4ce1-afff-a776a7906280
Source identifiers:
410263
Local pid:
pubs:410263

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP