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Plasmodium berghei infection: dichloroacetate improves survival in rats with lactic acidosis.

Abstract:

The kinetics of Plasmodium berghei infection and the development of lactic acidosis, hypoglycemia, and anemia were defined in young Wistar rats. This model of metabolic dysfunction, which is similar to that of severe human malaria, was used to test the hypothesis that dichloroacetate, a treatment for lactic acidosis, prolonged survival in rats receiving a single antimalarial dose of quinine (20 mg/kg). Rats with hyperlactatemia (lactate > 5 mmol/liter, N = 183) were randomized to receive e...

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Publication status:
Published

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Publisher copy:
10.1006/expr.1995.1078

Authors


Holloway, PA More by this author
Chapman, D More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
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Journal:
Experimental parasitology
Volume:
80
Issue:
4
Pages:
624-632
Publication date:
1995-06-05
DOI:
EISSN:
1090-2449
ISSN:
0014-4894
URN:
uuid:9e3d1ab8-5d11-4ad2-a2b3-a224fa6ff935
Source identifiers:
35690
Local pid:
pubs:35690

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