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Phylogenetic distribution of CMP-Neu5Ac Hydroxylase (CMAH), the enzyme synthetizing the proinflammatory human xenoantigen Neu5Gc

Abstract:

The enzyme CMP-N-acetylneuraminic acid hydroxylase (CMAH) is responsible for the synthesis of N-glycolylneuraminic acid (Neu5Gc), a sialic acid present on the cell surface proteins of most deuterostomes. The CMAH gene is thought to be present in most deuterostomes, but it has been inactivated in a number of lineages, including humans. The inability of humans to synthesize Neu5Gc has had several evolutionary and biomedical implications. Remarkably, Neu5Gc is a xenoantigen for humans, and consu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/gbe/evx251

Authors


Kulkarni, A More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
Berninsone, PM More by this author
Alvarez-Ponce, D More by this author
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Funding agency for:
Berninsone, PM
Publisher:
Oxford University Press Publisher's website
Journal:
Genome Biology and Evolution Journal website
Volume:
10
Issue:
1
Pages:
207–219
Publication date:
2017-12-30
Acceptance date:
2017-11-29
DOI:
ISSN:
1759-6653
Pubs id:
pubs:836288
URN:
uri:9e3460be-eaaf-4f52-a7aa-e9bd4e3f8053
UUID:
uuid:9e3460be-eaaf-4f52-a7aa-e9bd4e3f8053
Local pid:
pubs:836288
Language:
English
Keywords:

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