A trigonal form of the idarubicin:d(CGATCG) complex; crystal and molecular structure at 2.0 A resolution.

Journal article

The X-ray crystal structure of the complex between the anthracycline idarubicin and d(CGATCG) has been solved by molecular replacement and refined to a resolution of 2.0 A. The final R-factor is 0.19 for 3768 reflections with Fo > or = 2 sigma (Fo). The complex crystallizes in the trigonal space group P31 with unit cell parameters a = b = 52.996(4), c = 33.065(2) A, alpha = beta = 90 degree, gamma = 120 degree. The asymmetric unit consists of two duplexes, each one being complexed with two...

Expand abstract

Authors: Dautant, A; Langlois d'Estaintot, B; Gallois, B; Brown, T; Hunter, W

• Publication status: Published
• Journal: Nucleic acids research
• Volume: 23
• Issue: 10
• Pages: 1710-1716
• Publication date: 1995-05-01
• DOI: 10.1093/nar/23.10.1710
• EISSN: 1362-4962
• ISSN: 0305-1048
• Language: English
• Keywords: Oligodeoxyribonucleotides; Crystallography, X-Ray; Models, Molecular; Nucleic Acid Conformation; DNA; Base Sequence; Molecular Conformation; Idarubicin; Intercalating Agents