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Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study

Abstract:

Background

Earlier puberty is widely linked with future obesity and cardiometabolic disease. We examined whether age at puberty onset likely influences adiposity and cardiometabolic traits independent of childhood adiposity.

Methods and findings

One-sample Mendelian randomisation (MR) analyses were conducted on up to 3,611 white-European female and male offspring from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort recruited at birth via mother...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.1002641

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Role:
Author
ORCID:
0000-0001-6892-8786
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Role:
Author
ORCID:
0000-0003-0574-5071
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Role:
Author
ORCID:
0000-0003-3543-6480
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Diabetes UK More from this funder
National Institute for Health Research More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
15
Issue:
8
Pages:
e1002641
Publication date:
2018-08-28
Acceptance date:
2018-07-25
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Pubs id:
pubs:915266
URN:
uri:9e21a0c0-a8a9-4ad3-a1e1-8514c9129fe8
UUID:
uuid:9e21a0c0-a8a9-4ad3-a1e1-8514c9129fe8
Local pid:
pubs:915266
Language:
English
Keywords:

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