- Abstract:
-
Background
Earlier puberty is widely linked with future obesity and cardiometabolic disease. We examined whether age at puberty onset likely influences adiposity and cardiometabolic traits independent of childhood adiposity.
Methods and findings
One-sample Mendelian randomisation (MR) analyses were conducted on up to 3,611 white-European female and male offspring from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort recruited at birth via mother...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 4.8MB)
-
- Publisher copy:
- 10.1371/journal.pmed.1002641
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Medicine Journal website
- Volume:
- 15
- Issue:
- 8
- Pages:
- e1002641
- Publication date:
- 2018-08-28
- Acceptance date:
- 2018-07-25
- DOI:
- EISSN:
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1549-1676
- ISSN:
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1549-1277
- Pubs id:
-
pubs:915266
- URN:
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uri:9e21a0c0-a8a9-4ad3-a1e1-8514c9129fe8
- UUID:
-
uuid:9e21a0c0-a8a9-4ad3-a1e1-8514c9129fe8
- Local pid:
- pubs:915266
- Language:
- English
- Keywords:
- Copyright holder:
- Bell et al
- Copyright date:
- 2018
- Notes:
- © 2018 Bell et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study
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Diabetes UK
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National Institute for Health Research
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