Journal article icon

Journal article

Budding yeast RNA polymerases I and II employ parallel mechanisms of transcriptional termination.

Abstract:

Both RNA polymerase I and II (Pol I and Pol II) in budding yeast employ a functionally homologous "torpedo-like" mechanism to promote transcriptional termination. For two well-defined Pol II-transcribed genes, CYC1 and PMA1, we demonstrate that both Rat1p exonuclease and Sen1p helicase are required for efficient termination by promoting degradation of the nascent transcript associated with Pol II, following mRNA 3' end processing. Similarly, Pol I termination relies on prior Rnt1p cleavage at...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1101/gad.463408

Authors


Kawauchi, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Genes and development
Volume:
22
Issue:
8
Pages:
1082-1092
Publication date:
2008-04-05
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
URN:
uuid:9e1cf4e9-69d0-485b-a240-31a5962f6395
Source identifiers:
12005
Local pid:
pubs:12005

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP