Journal article
The threshold of protection from liver-stage malaria relies on a fine balance between the number of infected hepatocytes and effector CD8+ T cells present in the liver
- Abstract:
-
Since the demonstration of sterile protection afforded by injection of irradiated sporozoites, CD8+ T cells have been shown to play a significant role in protection from liver-stage malaria. This is, however, dependent on the presence of an extremely high number of circulating effector cells, thought to be necessary to scan, locate and kill infected hepatocytes in the short time that parasites are present in the liver. We utilised an adoptive transfer model to elucidate the kinetics of the ef...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 4.4MB, Terms of use)
-
- Publisher copy:
- 10.4049/jimmunol.1601209
Authors
Funding
+ Foundation for the National Institute of Health
More from this funder
Grant:
ChallengesinGlobalHealthInitiative(HILL05GCGH0
Gr
Bibliographic Details
- Publisher:
- American Association of Immunologists
- Journal:
- Journal of Immunology More from this journal
- Volume:
- 198
- Issue:
- 5
- Pages:
- 2006-2016
- Publication date:
- 2017-01-01
- Acceptance date:
- 2016-12-19
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
Item Description
- Keywords:
- Pubs id:
-
pubs:666784
- UUID:
-
uuid:9e186598-916c-4346-b44a-00df516667e9
- Local pid:
-
pubs:666784
- Deposit date:
-
2016-12-21
Terms of use
- Copyright holder:
- Spencer et al
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 The Authors.
This is an open-access article distributed under the terms of the CC-BY 3.0 Unported license.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record