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Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohorts

Abstract:

Background: Both genome-wide association studies and candidate gene studies have reported that the major determinant of plasma levels of the Lipoprotein (a) [Lp(a)] reside within the LPA locus on chromosome 6. We have used data from the HumanCVD BeadChip to explore the contribution of other candidate genes determining Lp(a) levels. Methods: 48,032 single nucleotide polymorphisms (SNPs) from the Illumina HumanCVD BeadChip were genotyped in 5059 participants of the Whitehall II study (WHII) of ...

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Journal:
Atherosclerosis
Volume:
217
Issue:
2
Pages:
447-451
Publication date:
2011-08-05
DOI:
EISSN:
1879-1484
ISSN:
0021-9150
URN:
uuid:9e16babe-cdb8-47bc-85f9-0d822d0d22e0
Source identifiers:
170407
Local pid:
pubs:170407

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