Journal article
An online experimental medicine trial on the effect of 28-day simvastatin administration on emotional processing, reward learning, working memory and salivary cortisol in healthy volunteers at risk for depression: OxSTEP protocol
- Abstract:
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Background: Evidence suggests inflammation may be a key mechanism by which psychosocial stress, including loneliness, predisposes to depression. Observational and clinical studies have suggested simvastatin, with its anti-inflammatory properties, may have a potential use in the treatment of depression. Previous experimental medicine trials investigating 7-day use of statins showed conflicting results, with simvastatin displaying a more positive effect on emotional pro...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 471.4KB, Terms of use)
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- Publisher copy:
- 10.1192/bjo.2023.44
Authors
Funding
Bibliographic Details
- Publisher:
- Cambridge University Press
- Journal:
- BJPsych Open More from this journal
- Volume:
- 9
- Issue:
- 4
- Article number:
- e110
- Publication date:
- 2023-06-14
- Acceptance date:
- 2023-06-01
- DOI:
- EISSN:
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2056-4724
- Pmid:
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37313755
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1407651
- Local pid:
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pubs:1407651
- Deposit date:
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2023-06-22
Terms of use
- Copyright holder:
- Waters et al.
- Copyright date:
- 2023
- Rights statement:
- Copyright © The Author(s), 2023. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
- Licence:
- CC Attribution (CC BY)
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