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Tripartite sequences within and 3' to the sea urchin H2A histone gene display properties associated with a transcriptional termination process.

Abstract:

We have defined a DNA sequence that behaves as an RNA polymerase II termination signal by using the human HeLa cell transient expression system. Surprisingly, this sequence is tripartite, including part of the coding region of the sea urchin H2A histone gene together with two separate sequences in the 3' flanking region of the gene. We demonstrate that this signal functions both in its normal gene environment and also when placed within the human alpha-globin gene. However, we have failed to ...

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Publication status:
Published

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Authors


Johnson, MR More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Molecular and cellular biology
Volume:
6
Issue:
11
Pages:
4008-4018
Publication date:
1986-11-05
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:9e1497dd-1189-415c-86c9-e635ba76c29d
Source identifiers:
23436
Local pid:
pubs:23436

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