Journal article icon

Journal article

RNA interference-mediated inhibition of hepatocyte nuclear factor 1alpha identifies target genes.

Abstract:

Hepatocyte nuclear factor 1alpha (HNF1alpha) is a homeodomain transcription factor that is central to co-ordinated differentiation of a number of cell lineages, including hepatocytes in the liver and islet cells in the pancreas. HNF1alpha interacts directly with other transcription factors and co-factors and is involved in chromatin modification to alter gene expression. To further investigate the pivotal role of HNF1alpha in transcriptional control pathways we utilized RNA interference. An s...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Morris, KJ More by this author
Arvide, EM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, Biomedical Research Centre, Molecular Medicine
Journal:
Biochimica et biophysica acta
Volume:
1779
Issue:
5
Pages:
341-346
Publication date:
2008-05-05
DOI:
ISSN:
0006-3002
URN:
uuid:9e11bed0-d742-466b-a263-13a3e3279d3b
Source identifiers:
124853
Local pid:
pubs:124853

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP