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Glycoprotein synthesis: From glycobiological tools to tailor-made catalysts

Abstract:
The synthesis of pure, well-defined glycoproteins is essential to the study of the host of biological processes that they mediate. The use of a combined site-directed mutagenesis and chemical modification strategy allows the site-selective synthesis of homogenous glycoproteins, the determination of precise structure-activity relationships and the design of new synthetic catalysts. This general and powerful method is reviewed in the context of existing preparative techniques and the wide-ranging applications of glycoproteins are highlighted.
Publication status:
Published

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Publisher copy:
10.1055/s-1999-2865

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author


Publisher:
Georg Thieme Verlag
Journal:
SYNLETT More from this journal
Volume:
1999
Issue:
9
Pages:
1495-1507
Publication date:
1999-09-01
DOI:
EISSN:
1437-2096
ISSN:
0936-5214


Language:
English
Keywords:
Pubs id:
pubs:52105
UUID:
uuid:9e0fbcff-8485-4c99-90e1-a7fa8c8f3b2e
Local pid:
pubs:52105
Source identifiers:
52105
Deposit date:
2012-12-19

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