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Journal article

The Menkes disease ATPase (ATP7A) is internalized via a Rac1-regulated, clathrin- and caveolae-independent pathway.

Abstract:

The Menkes disease gene encodes a P-type transmembrane ATPase (ATP7A) that translocates cytosolic copper ions across intracellular membranes of compartments along the secretory pathway. ATP7A moves from the trans-Golgi network (TGN) to the cell surface in response to exogenously added copper ions and recycles back to the TGN upon copper removal. The protein contains a C-terminal di-leucine motif necessary for internalization from the cell surface. In this study we show that ATP7A is internali...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddg166

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
Journal:
Human molecular genetics
Volume:
12
Issue:
13
Pages:
1523-1533
Publication date:
2003-07-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:9e08ee7c-bd98-4752-a59c-1c0d876f92dd
Source identifiers:
32387
Local pid:
pubs:32387

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