- Abstract:
-
The Menkes disease gene encodes a P-type transmembrane ATPase (ATP7A) that translocates cytosolic copper ions across intracellular membranes of compartments along the secretory pathway. ATP7A moves from the trans-Golgi network (TGN) to the cell surface in response to exogenously added copper ions and recycles back to the TGN upon copper removal. The protein contains a C-terminal di-leucine motif necessary for internalization from the cell surface. In this study we show that ATP7A is internali...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/hmg/ddg166
-
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- Journal:
- Human molecular genetics
- Volume:
- 12
- Issue:
- 13
- Pages:
- 1523-1533
- Publication date:
- 2003-07-05
- DOI:
- EISSN:
-
1460-2083
- ISSN:
-
0964-6906
- URN:
-
uuid:9e08ee7c-bd98-4752-a59c-1c0d876f92dd
- Source identifiers:
-
32387
- Local pid:
- pubs:32387
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
The Menkes disease ATPase (ATP7A) is internalized via a Rac1-regulated, clathrin- and caveolae-independent pathway.
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