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Pancreas storage in oxygenated perfluorodecalin does not restore post-transplant function of isolated pig islets pre-damaged by warm ischemia.

Abstract:

BACKGROUND: Cold storage in oxygenated perfluorodecalin (PFD) restores transplant function of ischemically damaged dog pancreata and reduces the impact of cold ischemia on recovery of isolated human islets. Whether PFD storage can improve islet isolation from pancreata exposed to significant warm ischemia (WI) is unclear yet. The present study aimed to clarify this question in adult pigs. METHODS: After exsanguination, the intestine was removed immediately or left in the cavity for 30 min of...

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Bretzel, RG More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Journal:
Xenotransplantation
Volume:
13
Issue:
5
Pages:
465-470
Publication date:
2006-09-05
DOI:
EISSN:
1399-3089
ISSN:
0908-665X
URN:
uuid:9de848f1-0bcc-4840-b5ed-a31925eaf4e5
Source identifiers:
268661
Local pid:
pubs:268661

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