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Journal article

T₂-weighted MRI detects presymptomatic pathology in the SOD1 mouse model of ALS.

Abstract:

Neuroinflammation has been identified as a potential therapeutic target in amyotrophic lateral sclerosis (ALS), but relevant biomarkers are needed. The superoxide dismutase (SOD1)(G93A) transgenic mouse model of ALS offers a unique opportunity to study and potentially manipulate presymptomatic pathology. While T₂-weighted magnetic resonance imaging (MRI) has been shown to be sensitive to pathologic changes at symptom onset, no earlier biomarkers were previously identified and the underlying h...

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Publication status:
Published

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Publisher copy:
10.1038/jcbfm.2014.19

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Journal:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Volume:
34
Issue:
5
Pages:
785-793
Publication date:
2014-05-05
DOI:
EISSN:
1559-7016
ISSN:
0271-678X
URN:
uuid:9de5f21e-f6cb-4442-a2a1-e7395815f99d
Source identifiers:
447643
Local pid:
pubs:447643

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