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A metabolite-sensitive, thermodynamically-constrained model of cardiac cross-bridge cycling: Implications for force development during ischemia

Abstract:

We present a metabolically regulated model of cardiac active force generation with which we investigate the effects of ischemia on maximum forceproduction. Our model, based on the Rice et al. (2008) model of cross-bridge kinetics, reproduces many of the observed effects of MgATP, MgADP, Pi and H+ on force development while still retaining the force/length/Ca2+ properties of the original model. We introduce three new parameters to account for the competitive binding of H+ to the Ca2+ binding s...

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Kenneth Tran More by this author
Denis Loiselle More by this author
E. J. Crampin More by this author
Publication date:
2009
URN:
uuid:9dd6ab91-8699-4161-a30f-ebb06300d095
Local pid:
oai:eprints.maths.ox.ac.uk:855

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