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Genomic analysis of local variation and recent evolution in Plasmodium vivax

Abstract:

The widespread distribution and relapsing nature of Plasmodium vivax infection present major challenges for malaria elimination. To characterise the genetic diversity of this parasite within individual infections and across the population, we performed deep genome sequencing of >200 clinical samples collected across the Asia-Pacific region, and analysed data on >300,000 SNPs and 9 regions of the genome with large structural variations. Individual infections showed complex patterns of ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/ng.3599

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Strategic
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine, Thailand/Laos MOP
Role:
Author
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Grant:
098051, 090770/Z/09/Z
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Genetics Journal website
Volume:
48
Pages:
959–964
Publication date:
2016-01-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:9dd25c92-466b-4ff6-a56e-d9b7f5a20d25
Source identifiers:
617207
Local pid:
pubs:617207

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