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Dimorphic Plasmodium falciparum merozoite surface protein-1 epitopes turn off memory T cells and interfere with T cell priming.

Abstract:

The leading blood-stage malaria vaccine candidate antigen, Plasmodium falciparum merozoite surface protein-1 (MSP-1) occurs in two major allelic types worldwide. The molecular basis promoting this stable dimorphism is unknown. In this study, we have shown that allelic altered peptide ligand (APL) T cell epitopes of MSP-1 mutually inhibited IFN-gamma secretion as well as proliferation of CD4+ T cells in 27/34 malaria exposed Gambian volunteers. Besides this inhibition of malaria-specific immun...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200526010

Authors


Flanagan, KL More by this author
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Journal:
European journal of immunology
Volume:
36
Issue:
5
Pages:
1168-1178
Publication date:
2006-05-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:9dcd44da-9b3e-45a3-b1a2-574868195a49
Source identifiers:
33445
Local pid:
pubs:33445

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