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Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells.

Abstract:

While a significant amount is known about the biochemical signaling pathways of the Rho family GTPase Cdc42, a better understanding of how these signaling networks are coordinated in cells is required. In particular, the predominant subcellular sites where GTP-bound Cdc42 binds to its effectors, such as p21-activated kinase 1 (PAK1) and N-WASP, a homolog of the Wiskott-Aldritch syndrome protein, are still undetermined. Recent fluorescence resonance energy transfer (FRET) imaging experiments u...

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Publication status:
Published

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Authors


Parsons, M More by this author
Monypenny, J More by this author
Ameer-Beg, SM More by this author
Millard, TH More by this author
Machesky, LM More by this author
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Journal:
Molecular and cellular biology
Volume:
25
Issue:
5
Pages:
1680-1695
Publication date:
2005-03-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:9dc74fa2-10f7-442b-afea-e3725155d0e1
Source identifiers:
130977
Local pid:
pubs:130977

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