Macrophage-osteoclast differentiation and bone resorption in osteoarthrotic subchondral acetabular cysts.

Journal article

A macrophage infiltrate is commonly found in enlarging subchondral cysts in osteoarthrosis (OA) and the surrounding bone. To determine whether osteoclast differentiation by these cells contributes to the increase in the number of osteoclasts and bone resorption that accompanies OA cyst enlargement, we isolated macrophages from the wall of OA cysts and co-cultured them with osteoblast-like UMR106 cells in the presence or absence of 1,25(OH)2D3 and M-CSE After 14 days of incubation, co-cultures...

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Authors: Sabokbar, A; Crawford, R; Murray, D; Athanasou, N

• Publication status: Published
• Journal: Acta orthopaedica Scandinavica
• Volume: 71
• Issue: 3
• Pages: 255-261
• Publication date: 2000-06-01
• DOI: 10.1080/000164700317411843
• EISSN: 1745-3682
• ISSN: 0001-6470
• Language: English
• Keywords: Calcitriol; Receptors, Vitronectin; Acetabulum; Acid Phosphatase; Middle Aged; Aged; Humans; Cell Differentiation; Osteoarthritis; Coculture Techniques; Male; Isoenzymes; Macrophages; Macrophage-1 Antigen; Bone Resorption; Femur Head; Macrophage Colony-Stimulating Factor; Osteoclasts; Bone Cysts; Female