Journal article icon

Journal article

Spontaneous B cell hyperactivity in autoimmune-prone MRL mice.

Abstract:

The MRL-lpr/lpr mouse strain is a commonly used model of the human autoimmune disease systemic lupus erythematosus (SLE). Although much is known about the contribution of the lpr Fas mutation to B cell tolerance breakdown, the role of the genetic background of the MRL strain itself is less well explored. In this study, we use the MD4 anti-hen egg lysozyme Ig (IgHEL) transgenic system to explore B cell function in MRL+/+ and non-autoimmune mice. We demonstrate that MRL IgHEL B cells show spont...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1093/intimm/dxl047

Authors


Rapsomaniki, E More by this author
Expand authors...
Journal:
International immunology
Volume:
18
Issue:
7
Pages:
1127-1137
Publication date:
2006-07-05
DOI:
EISSN:
1460-2377
ISSN:
0953-8178
URN:
uuid:9dbd0091-1e8f-45ce-a6dc-ce71090401c3
Source identifiers:
27324
Local pid:
pubs:27324

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP