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Effects of desferrioxamine on serum erythropoietin and ventilatory sensitivity to hypoxia in humans.

Abstract:

In cell culture, hypoxia stabilizes a transcriptional complex called hypoxia-inducible factor-1 (HIF-1) that increases erythropoietin (Epo) formation. One hallmark of HIF-1 responses is that they can be induced by iron chelation. The first aim of this study was to examine whether an infusion of desferrioxamine (DFO) increased serum Epo in humans. If so, this might provide a paradigm for identifying other HIF-1 responses in humans. Consequently a second aim was to determine whether an infusion...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Maxwell, PH More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Journal of applied physiology (Bethesda, Md. : 1985)
Volume:
89
Issue:
2
Pages:
680-686
Publication date:
2000-08-05
EISSN:
1522-1601
ISSN:
8750-7587
URN:
uuid:9dba5995-be84-4464-a719-554a12b7c7e2
Source identifiers:
114122
Local pid:
pubs:114122

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