Effects of desferrioxamine on serum erythropoietin and ventilatory sensitivity to hypoxia in humans.
In cell culture, hypoxia stabilizes a transcriptional complex called hypoxia-inducible factor-1 (HIF-1) that increases erythropoietin (Epo) formation. One hallmark of HIF-1 responses is that they can be induced by iron chelation. The first aim of this study was to examine whether an infusion of desferrioxamine (DFO) increased serum Epo in humans. If so, this might provide a paradigm for identifying other HIF-1 responses in humans. Consequently a second aim was to determine whether an infusion...Expand abstract
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- Journal of applied physiology (Bethesda, Md. : 1985)
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