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Adult murine T cells activated in vitro by alpha-fetoprotein and naturally occurring T cells in newborn mice: identity in function and cell surface differentiation antigens.

Abstract:

Murine alpha-fetoprotein (alphaFP) has been shown to suppress T cell-dependent antibody responses in vitro but not T cell-independent responses. Our earlier preliminary findings indicated that such inhibitory effects are mediated via activated T cells. In this study, using alphaFP as the inducing agent, we have analyzed cells generated in vitro from adult spleen cells with regard to function and surface markers and compared the cells to the naturally occurring splenic T cells of newborn mice,...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.75.6.2897

Authors


Murgita, RA More by this author
Kontiainen, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Wigzell, H More by this author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
75
Issue:
6
Pages:
2897-2901
Publication date:
1978-06-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:9db02f90-3471-4ea8-bcad-d2038883c777
Source identifiers:
35716
Local pid:
pubs:35716

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