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Serum autoantibody biomarkers for age-related macular degeneration and possible regulators of neovascularization.

Abstract:

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrial counties. Its pathogenesis is at least partially mediated by immunological factors, including a possible autoimmune response. To date, only a few antibodies have been identified in sera from patients with AMD. In order to reveal an autoantibody profile for AMD and identify biomarkers for progression of this disease, we have performed an antigen microarray analysis of serum samples from patients...

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Publisher copy:
10.1016/j.yexmp.2011.09.017

Authors


Morohoshi, K More by this author
Ohbayashi, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Grossniklaus, HE More by this author
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Journal:
Experimental and molecular pathology
Volume:
92
Issue:
1
Pages:
64-73
Publication date:
2012-02-05
DOI:
EISSN:
1096-0945
ISSN:
0014-4800
URN:
uuid:9dad009c-e283-40a5-a93f-5b330702a83a
Source identifiers:
254208
Local pid:
pubs:254208

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