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A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution.

Abstract:

Initially thought to play a restricted role in calcium homeostasis, the pleiotropic actions of vitamin D in biology and their clinical significance are only now becoming apparent. However, the mode of action of vitamin D, through its cognate nuclear vitamin D receptor (VDR), and its contribution to diverse disorders, remain poorly understood. We determined VDR binding throughout the human genome using chromatin immunoprecipitation followed by massively parallel DNA sequencing (ChIP-seq). Afte...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1101/gr.107920.110

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Funding agency for:
Ramagopalan, SV
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Funding agency for:
Berlanga, AJ
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Funding agency for:
Maugeri, NJ
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Funding agency for:
Lincoln, MR
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Funding agency for:
Burrell, A
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Publisher:
Cold Spring Harbor Laboratory Press Publisher's website
Journal:
Genome research Journal website
Volume:
20
Issue:
10
Pages:
1352-1360
Publication date:
2010-10-05
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
URN:
uuid:9da19a7f-4fa5-4045-832c-fcbcfe37be90
Source identifiers:
67493
Local pid:
pubs:67493

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