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Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces

Abstract:

Epigenetics is of rapidly growing field in drug discovery. Of particular interest is the role of post‐translational modifications to histone and the proteins that read, write, and erase such modifications. The development of inhibitors for reader domains has focused on single domains. One of the major difficulties of designing inhibitors for reader domains, is that with the notable exception of bromodomains, they tend not to possess a well enclosed binding site amenable to small molecule inhi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/cmdc.201800030

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
Oxford college:
Corpus Christi College
ORCID:
0000-0002-8950-7646
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Genomics Consortium
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Genomics Consortium
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
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Publisher:
Wiley‐VCH Verlag Publisher's website
Journal:
ChemMedChem Journal website
Volume:
13
Issue:
10
Pages:
1051-1057
Publication date:
2018-04-17
Acceptance date:
2018-03-16
DOI:
ISSN:
1860-7179
Pubs id:
pubs:831779
URN:
uri:9d83f9ca-56be-40af-b86c-3044fc838237
UUID:
uuid:9d83f9ca-56be-40af-b86c-3044fc838237
Local pid:
pubs:831779

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