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Tumor protection by IL-7 secreting whole cell vaccine is merely mediated by NK1.1-positive cells.

Abstract:

As prostatic epithelia constitutively produce interleukin 7 (IL-7), also responsible for the development and hemostasis of T cells and NK cells, it is important to examine its ability to protect against prostate cancer, and its possible role in future vaccine strategies against prostate cancer. RM-9/mIL-7 cells were used as mIL-7 secreting whole cell vaccine to prevent tumor growth upon a subcutaneous RM-9 challenge in C57bl/6 mice. The RM-9/mIL-7 vaccination effect was studied by CD3, CD4, C...

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Journal:
Journal of immunotherapy (Hagerstown, Md. : 1997)
Volume:
35
Issue:
2
Pages:
125-130
Publication date:
2012-01-01
DOI:
EISSN:
1537-4513
ISSN:
1524-9557
URN:
uuid:9d803f62-7b63-493f-90de-238cacb6bedc
Source identifiers:
480329
Local pid:
pubs:480329

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