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Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade.

Abstract:

Mitotic index is an important component of histologic grade and has an etiologic role in breast tumorigenesis. Several small candidate gene studies have reported associations between variation in mitotic genes and breast cancer risk. We measured associations between 2156 single nucleotide polymorphisms (SNPs) from 194 mitotic genes and breast cancer risk, overall and by histologic grade, in the Breast Cancer Association Consortium (BCAC) iCOGS study (n = 39 067 cases; n = 42 106 controls). SN...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddu300

Authors


Purrington, KS More by this author
Slettedahl, S More by this author
Michailidou, K More by this author
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Journal:
Human molecular genetics
Volume:
23
Issue:
22
Pages:
6034-6046
Publication date:
2014-11-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:9d78c190-33a0-4218-b490-b83ad539ece3
Source identifiers:
469516
Local pid:
pubs:469516

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