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Immediate dysfunction of vaccine-elicited CD8+ T cells primed in the absence of CD4+ T cells

Abstract:

CD4(+) T cell help is critical for optimal CD8(+) T cell memory differentiation and maintenance in many experimental systems. In addition, many reports have identified reduced primary CD8(+) T cell responses in the absence of CD4(+) T cell help, which often coincides with reduced Ag or pathogen clearance. In this study, we demonstrate that absence of CD4(+) T cells at the time of adenovirus vector immunization of mice led to immediate impairments in early CD8(+) T cell functionality and diffe...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.4049/jimmunol.1600591

Authors


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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Larocca, RA More by this author
Penaloza-MacMaster, P More by this author
Badamchi-Zadeh, A More by this author
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Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
197
Issue:
5
Pages:
1809-1822
Publication date:
2016-09-05
Acceptance date:
2016-06-20
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Pubs id:
pubs:636745
URN:
uri:9d72b196-c2b3-4d80-920c-b0360058c630
UUID:
uuid:9d72b196-c2b3-4d80-920c-b0360058c630
Local pid:
pubs:636745
Language:
English

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