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Journal article

Translating the effects of statins: from redox regulation to suppression of vascular wall inflammation.

Abstract:

Vascular oxidative stress is a key feature of atherogenesis, and targeting vascular redox signalling is a rational therapeutic goal in vascular disease pathogenesis. 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors or statins are potent lipid-lowering drugs that improve cardiovascular outcomes. It is now widely accepted that cardiovascular disease prevention by statins is dependent not only on their lipid lowering effects, but also on their beneficial effects on vascular redox signalling....

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Publication status:
Published

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Publisher copy:
10.1160/th12-05-0337

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Role:
Author
Journal:
Thrombosis and haemostasis
Volume:
108
Issue:
5
Pages:
840-848
Publication date:
2012-11-05
DOI:
ISSN:
0340-6245
URN:
uuid:9d6d4d4f-30ce-4de6-b2b5-c3704ba1532a
Source identifiers:
345696
Local pid:
pubs:345696

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