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Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction

Abstract:

Teneurins are ancient cell-cell adhesion receptors that are vital for brain development and synapse organisation. They originated in early metazoan evolution through a horizontal gene transfer event when a bacterial YD-repeat toxin fused to a eukaryotic receptor. We present X-ray crystallography and cryo-EM structures of two Teneurins, revealing a ~200 kDa extracellular super-fold in which eight sub-domains form an intricate structure centred on a spiralling YD-repeat shell. An alternatively ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41467-018-03460-0

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
ORCID:
0000-0002-2485-1833
Meijer, DH More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
van Bezouwen, LS More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
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Funding agency for:
Jackson, VA
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Funding agency for:
Seiradake, E
Publisher:
Macmillan Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
1
Pages:
Article: 1079
Publication date:
2018-03-14
DOI:
ISSN:
2041-1723
Pubs id:
pubs:831375
URN:
uri:9d6412cd-7463-4d0b-80ea-c2d65e962dd7
UUID:
uuid:9d6412cd-7463-4d0b-80ea-c2d65e962dd7
Local pid:
pubs:831375

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