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Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling.

Abstract:

Endothelial nitric-oxide synthase (eNOS) is a critical regulator of vascular homeostasis by generation of NO that is dependent on the cofactor tetrahydrobiopterin (BH4). When BH4 availability is limiting, eNOS becomes "uncoupled," resulting in superoxide production in place of NO. Recent evidence suggests that eNOS uncoupling can also be induced by S-glutathionylation, although the functional relationships between BH4 and S-glutathionylation remain unknown. To address a possible role for BH4 ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m112.415992

Authors


Crabtree, MJ More by this author
Batchelor, H More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Journal:
The Journal of biological chemistry
Volume:
288
Issue:
1
Pages:
561-569
Publication date:
2013-01-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:9d5b9938-2c4c-4a32-8e01-bc68cd5eac20
Source identifiers:
358330
Local pid:
pubs:358330

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