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Effects of acute tryptophan depletion on prefrontal-amygdala connectivity while viewing facial signals of aggression.

Abstract:

BACKGROUND: Reduced levels of serotonin (5-HT) within prefrontal cortex (PFC)-amygdala circuits have long been implicated in impulsive aggression. However, whether lowering 5-HT alters the dynamic interplay between the PFC and the amygdala has not been directly tested in humans. It is known that manipulating 5-HT via acute tryptophan depletion (ATD) causes variable effects on brain responses to a variety of emotional stimuli, but it remains unclear whether ATD affects functional connectivity ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
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Journal:
Biological psychiatry
Volume:
71
Issue:
1
Pages:
36-43
Publication date:
2012-01-05
DOI:
EISSN:
1873-2402
ISSN:
0006-3223
URN:
uuid:9d58df9a-9f49-415d-8eb9-9fe6996fae4b
Source identifiers:
420728
Local pid:
pubs:420728

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