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Genetic risk score Mendelian randomization shows that obesity measured as body mass index, but not waist:hip ratio, is causal for endometrial cancer.

Abstract:

Background

The strongest known risk factorfor endometrial cancer (EC) is obesity. To determine whether single nucleotide polymorphisms (SNPs) associated with increased body mass index (BMI) or waist-hip ratio (WHR) are associated with EC risk, independent of measured BMI, we investigated relationships between 77 BMI and 47 WHR SNPs and EC in 6,609 cases and 37,926 country-matched controls.

Methods

Logistic regression analysis and fixed-effects meta-analysis were u...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


Painter, JN More by this author
O'Mara, TA More by this author
Marquart, L More by this author
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Funding agency for:
Tomlinson, Ian
Oxford Comprehensive Biomedical Research Centre More from this funder
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Publisher:
American Association for Cancer Research Publisher's website
Journal:
Cancer Epidemiology, Biomarkers & Prevention Journal website
Publication date:
2016-08-05
Acceptance date:
2016-06-15
DOI:
ISSN:
1538-7755 and 1055-9965
Pubs id:
pubs:640491
URN:
uri:9d4accc3-c33b-4515-bd60-77a3e79afae1
UUID:
uuid:9d4accc3-c33b-4515-bd60-77a3e79afae1
Local pid:
pubs:640491

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