Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus.

DeBenedette, MA; Wen, T; Bachmann, MF; Ohashi, PS; Barber, BH; Stocking, KL; Peschon, JJ; Watts, TH

Abstract:

4-1BB ligand (4-1BBL) is a member of the TNF family expressed on activated APC. 4-1BBL binds to 4-1BB (CD137) on activated CD4 and CD8 T cells and in conjunction with strong signals through the TCR provides a CD28-independent costimulatory signal leading to high level IL-2 production by primary resting T cells. Here we report the immunological characterization of mice lacking 4-1BBL and of mice lacking both 4-1BBL and CD28. 4-1BBL-/- mice mount neutralizing IgM and IgG responses to vesicular ...

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APA Style

DeBenedette, M. A., Wen, T., Bachmann, M. F., Ohashi, P. S., Barber, B. H., Stocking, K. L., Peschon, J. J., & Watts, T. H. (1999). Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus. Journal of Immunology (Baltimore, Md. : 1950), 163(9), 4833–4841.

MLA Style

DeBenedette, M. A., et al. “Analysis of 4-1BB Ligand (4-1BBL)-Deficient Mice and of Mice Lacking Both 4-1BBL and CD28 Reveals a Role for 4-1BBL in Skin Allograft Rejection and in the Cytotoxic T Cell Response to Influenza Virus.” Journal of Immunology (Baltimore, Md. : 1950), vol. 163, no. 9, 1999, pp. 4833–41.

Chicago Style

DeBenedette, MA, T Wen, MF Bachmann, PS Ohashi, BH Barber, KL Stocking, JJ Peschon, and TH Watts. 1999. “Analysis of 4-1BB Ligand (4-1BBL)-Deficient Mice and of Mice Lacking Both 4-1BBL and CD28 Reveals a Role for 4-1BBL in Skin Allograft Rejection and in the Cytotoxic T Cell Response to Influenza Virus.” Journal of Immunology (Baltimore, Md. : 1950) 163 (9): 4833–41.
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