Journal article
Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus.
- Abstract:
-
4-1BB ligand (4-1BBL) is a member of the TNF family expressed on activated APC. 4-1BBL binds to 4-1BB (CD137) on activated CD4 and CD8 T cells and in conjunction with strong signals through the TCR provides a CD28-independent costimulatory signal leading to high level IL-2 production by primary resting T cells. Here we report the immunological characterization of mice lacking 4-1BBL and of mice lacking both 4-1BBL and CD28. 4-1BBL-/- mice mount neutralizing IgM and IgG responses to vesicular ...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Journal of Immunology
- Volume:
- 163
- Issue:
- 9
- Pages:
- 4833-4841
- Publication date:
- 1999-11-01
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- Source identifiers:
-
469225
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:469225
- UUID:
-
uuid:9d45f891-3d75-43fe-908e-00079e9474cc
- Local pid:
- pubs:469225
- Deposit date:
- 2014-06-17
Terms of use
- Copyright date:
- 1999
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