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Cloning, functional analysis and post-transcriptional regulation of a type II DNA topoisomerase from Leishmania infantum. A new potential target for anti-parasite drugs.

Abstract:

We identified a type II topoisomerase enzyme from Leishmania infantum, a parasite protozoon causing disease in humans. This protein, named Li topo II, which displays a variable C-terminal end, is located in the kinetoplast. The cloned gene encoding Li-TOP2 compensates for the slow growth of topo II-deficient mutants of Saccharomyces cerevisiae, resulting in a catalytically active DNA topoisomerase in yeast. Analysis of the specific mRNA levels of the Li-TOP2 gene showed variations throughout ...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gkg671

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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Condensed Matter Physics
Role:
Author
Journal:
Nucleic acids research
Volume:
31
Issue:
16
Pages:
4917-4928
Publication date:
2003-08-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:9d393b5a-9bf2-45b7-b372-e26e1b39ac52
Source identifiers:
155108
Local pid:
pubs:155108

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