- Abstract:
-
We identified a type II topoisomerase enzyme from Leishmania infantum, a parasite protozoon causing disease in humans. This protein, named Li topo II, which displays a variable C-terminal end, is located in the kinetoplast. The cloned gene encoding Li-TOP2 compensates for the slow growth of topo II-deficient mutants of Saccharomyces cerevisiae, resulting in a catalytically active DNA topoisomerase in yeast. Analysis of the specific mRNA levels of the Li-TOP2 gene showed variations throughout ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/nar/gkg671
-
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- Journal:
- Nucleic acids research
- Volume:
- 31
- Issue:
- 16
- Pages:
- 4917-4928
- Publication date:
- 2003-08-05
- DOI:
- EISSN:
-
1362-4962
- ISSN:
-
0305-1048
- URN:
-
uuid:9d393b5a-9bf2-45b7-b372-e26e1b39ac52
- Source identifiers:
-
155108
- Local pid:
- pubs:155108
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Cloning, functional analysis and post-transcriptional regulation of a type II DNA topoisomerase from Leishmania infantum. A new potential target for anti-parasite drugs.
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