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Modulatory effect of calmodulin-dependent kinase II (CaMKII) on sarcoplasmic reticulum Ca2+ handling and interval-force relations: a modelling study.

Abstract:

We hypothesize that slow inactivation of Ca2+/calmodulin-dependent kinase II (CaMKII) and its modulatory effect on sarcoplasmic reticulum (SR) Ca2+ handling are important for various interval-force (I-F) relations, in particular for the beat interval dependency in transient alternans during the decay of post-extrasystolic potentiation. We have developed a mathematical model of a single cardiomyocyte to integrate various I-F relations, including alternans, by incorporating a conceptual CaMKII ...

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Publication status:
Published

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Publisher copy:
10.1098/rsta.2006.1758

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
Volume:
364
Issue:
1842
Pages:
1107-1133
Publication date:
2006-05-05
DOI:
EISSN:
1471-2962
ISSN:
1364-503X
URN:
uuid:9d286aca-7ffb-4836-af28-0d8052dad170
Source identifiers:
237364
Local pid:
pubs:237364

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