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Estimating the risks of breast cancer radiotherapy: Evidence from modern radiation doses to the lungs and heart and from previous randomised trials

Abstract:

Purpose

Radiotherapy reduces the absolute risk of breast cancer mortality by a few percent in suitable women, but can cause second cancer or heart disease decades later. We estimated the absolute long-term risks of modern breast cancer radiotherapy.

Methods

First, a systematic literature review was performed of lung and heart doses in breast cancer regimens published during 2010-15.


Second, individual patient data meta-analyses of 40,781 women randomi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1200/JCO.2016.72.0722

Authors


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Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
More by this author
Department:
Oxford, MSD, Nuffield Department of Population Health
Anderson, SJ More by this author
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Medical Research Council More from this funder
Department of Health More from this funder
Publisher:
American Society of Clinical Oncology Publisher's website
Journal:
Journal of Clinical Oncology Journal website
Volume:
35
Issue:
15
Pages:
1641-1649
Publication date:
2017-03-05
Acceptance date:
2017-01-17
DOI:
EISSN:
1527-7755
ISSN:
0732-183X
Pubs id:
pubs:671730
URN:
uri:9cf9c89c-ff44-47da-93f4-22d8581f7c9b
UUID:
uuid:9cf9c89c-ff44-47da-93f4-22d8581f7c9b
Local pid:
pubs:671730

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