Journal article icon

Journal article

Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla

Abstract:

Intrathymic T-cell development is critically dependent on cortical and medullary thymic epithelial cells (TECs). Both epithelial subsets originate during early thymus organogenesis from progenitor cells that express the thymoproteasome subunit β5t, a typical feature of cortical TECs. Using in vivo lineage fate mapping, we demonstrate in mice that β5t(+) TEC progenitors give rise to the medullary TEC compartment early in life but significantly limit their contribution once the medulla has comp...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1002/eji.201545995

Authors


Expand authors...
Publisher:
Wiley Publisher's website
Journal:
European journal of immunology Journal website
Volume:
46
Issue:
4
Pages:
846-856
Publication date:
2016-01-18
Acceptance date:
2015-12-17
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Source identifiers:
584210
Language:
English
Keywords:
Pubs id:
pubs:584210
UUID:
uuid:9cee9e7f-a8cc-4ed2-9f3c-cae7e812ad38
Local pid:
pubs:584210
Deposit date:
2016-07-20

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP