- Abstract:
-
Intrathymic T-cell development is critically dependent on cortical and medullary thymic epithelial cells (TECs). Both epithelial subsets originate during early thymus organogenesis from progenitor cells that express the thymoproteasome subunit β5t, a typical feature of cortical TECs. Using in vivo lineage fate mapping, we demonstrate in mice that β5t(+) TEC progenitors give rise to the medullary TEC compartment early in life but significantly limit their contribution once the medulla has comp...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.1MB)
-
- Publisher copy:
- 10.1002/eji.201545995
-
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- Publisher:
- Wiley Online Library Publisher's website
- Journal:
- European journal of immunology Journal website
- Volume:
- 46
- Issue:
- 4
- Pages:
- 846-856
- Publication date:
- 2016-01-18
- Acceptance date:
- 2015-12-17
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- URN:
-
uuid:9cee9e7f-a8cc-4ed2-9f3c-cae7e812ad38
- Source identifiers:
-
584210
- Local pid:
- pubs:584210
- Paper number:
- 4
- Language:
- English
- Keywords:
- Copyright holder:
- Carlos Mayer et al.
- Copyright date:
- 2016
- Notes:
- This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Journal article
Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla
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