Journal article
Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla
- Abstract:
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Intrathymic T-cell development is critically dependent on cortical and medullary thymic epithelial cells (TECs). Both epithelial subsets originate during early thymus organogenesis from progenitor cells that express the thymoproteasome subunit β5t, a typical feature of cortical TECs. Using in vivo lineage fate mapping, we demonstrate in mice that β5t(+) TEC progenitors give rise to the medullary TEC compartment early in life but significantly limit their contribution once the medulla has comp...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.1MB)
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- Publisher copy:
- 10.1002/eji.201545995
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Authors
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- European journal of immunology Journal website
- Volume:
- 46
- Issue:
- 4
- Pages:
- 846-856
- Publication date:
- 2016-01-18
- Acceptance date:
- 2015-12-17
- DOI:
- EISSN:
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1521-4141
- ISSN:
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0014-2980
- Source identifiers:
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584210
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:584210
- UUID:
-
uuid:9cee9e7f-a8cc-4ed2-9f3c-cae7e812ad38
- Local pid:
- pubs:584210
- Deposit date:
- 2016-07-20
Terms of use
- Copyright holder:
- Carlos Mayer et al
- Copyright date:
- 2016
- Notes:
- This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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