- Abstract:
-
Generating a diverse B cell immunoglobulin repertoire is essential for protection against infection. The repertoire in humans can now be comprehensively measured by high-throughput sequencing. Using hepatitis B vaccination as a model, we determined how the total immunoglobulin sequence repertoire changes following antigen exposure in humans, and compared this to sequences from vaccine-specific sorted cells. Clonal sequence expansions were seen 7 days after vaccination, which correlated with v...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Funding agency for:
- Galson, JD
- Publisher:
- Elsevier Publisher's website
- Journal:
- EBioMedicine Journal website
- Volume:
- 2
- Issue:
- 12
- Pages:
- 2070-2079
- Publication date:
- 2015-12-05
- DOI:
- EISSN:
-
2352-3964
- ISSN:
-
2352-3964
- URN:
-
uuid:9cedb41f-4ec3-459e-92d3-a2524ed8f348
- Source identifiers:
-
600082
- Local pid:
- pubs:600082
- Language:
- English
- Keywords:
- Copyright holder:
- Galson et al.
- Copyright date:
- 2015
- Notes:
-
Copyright © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4.0/).
Journal article
Analysis of B cell repertoire dynamics following hepatitis B vaccination in humans, and enrichment of vaccine-specific antibody sequences
Actions
Authors
Funding
+ Biotechnology and Biological Sciences Research Council
More from this funder
GlaxoSmithKline Biologicals SA
More from this funder
National Institute for Health Research Oxford Biomedical Research Centre
More from this funder
Bibliographic Details
Item Description
Terms of use
Metrics
Altmetrics
Dimensions
If you are the owner of this record, you can report an update to it here: Report update to this record