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Analysis of B cell repertoire dynamics following hepatitis B vaccination in humans, and enrichment of vaccine-specific antibody sequences

Abstract:

Generating a diverse B cell immunoglobulin repertoire is essential for protection against infection. The repertoire in humans can now be comprehensively measured by high-throughput sequencing. Using hepatitis B vaccination as a model, we determined how the total immunoglobulin sequence repertoire changes following antigen exposure in humans, and compared this to sequences from vaccine-specific sorted cells. Clonal sequence expansions were seen 7 days after vaccination, which correlated with v...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.ebiom.2015.11.034

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics
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Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics
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GlaxoSmithKline Biologicals SA More from this funder
National Institute for Health Research Oxford Biomedical Research Centre More from this funder
Publisher:
Elsevier Publisher's website
Journal:
EBioMedicine Journal website
Volume:
2
Issue:
12
Pages:
2070-2079
Publication date:
2015-12-05
DOI:
EISSN:
2352-3964
ISSN:
2352-3964
URN:
uuid:9cedb41f-4ec3-459e-92d3-a2524ed8f348
Source identifiers:
600082
Local pid:
pubs:600082

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