- Abstract:
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Generating a diverse B cell immunoglobulin repertoire is essential for protection against infection. The repertoire in humans can now be comprehensively measured by high-throughput sequencing. Using hepatitis B vaccination as a model, we determined how the total immunoglobulin sequence repertoire changes following antigen exposure in humans, and compared this to sequences from vaccine-specific sorted cells. Clonal sequence expansions were seen 7 days after vaccination, which correlated with v...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.1mb)
-
- Publisher copy:
- 10.1016/j.ebiom.2015.11.034
-
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- Funding agency for:
- Galson, JD
- Publisher:
- Elsevier Publisher's website
- Journal:
- EBioMedicine Journal website
- Volume:
- 2
- Issue:
- 12
- Pages:
- 2070-2079
- Publication date:
- 2015-12-05
- DOI:
- EISSN:
-
2352-3964
- ISSN:
-
2352-3964
- URN:
-
uuid:9cedb41f-4ec3-459e-92d3-a2524ed8f348
- Source identifiers:
-
600082
- Local pid:
- pubs:600082
- Language:
- English
- Keywords:
- Copyright holder:
- Galson et al.
- Copyright date:
- 2015
- Notes:
-
Copyright © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4.0/).
Journal article
Analysis of B cell repertoire dynamics following hepatitis B vaccination in humans, and enrichment of vaccine-specific antibody sequences
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+ Biotechnology and Biological Sciences Research Council
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GlaxoSmithKline Biologicals SA
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National Institute for Health Research Oxford Biomedical Research Centre
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