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Development of spinal deformities in the tight-skin mouse

Abstract:

Tight-skin (TSK) mice are commonly used as an animal model to study the pathogenesis of Marfan syndrome (MFS), but little is known of their skeletal phenotype and in particular of the development of the spinal deformities, common in MFS. Here we examined growth of the axial skeletons of TSK and wild-type(B6) mice during their period of rapid growth. The whole bodies of mice, 4-12 weeks of age, were scanned after sacrifice, by micro-computed tomography (microCT). We reconstructed three-dimensi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/boneres.2016.53

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy & Genetics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy & Genetics
Publisher:
Springer Nature Publisher's website
Journal:
Bone Research Journal website
Volume:
5
Pages:
Article: 16053
Publication date:
2017-02-21
DOI:
EISSN:
2095-6231
ISSN:
2095-4700
Pubs id:
pubs:715233
URN:
uri:9ce7614a-99d8-42c4-875a-9fa90f361e68
UUID:
uuid:9ce7614a-99d8-42c4-875a-9fa90f361e68
Local pid:
pubs:715233
Language:
English

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