Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs.

Brookes, E; de Santiago, I; Hebenstreit, D; Morris, KJ; Carroll, T; Xie, SQ; Stock, JK; Heidemann, M; Eick, D; Nozaki, N; Kimura, H; Ragoussis, J; Teichmann, SA; Pombo, A

Abstract:

Polycomb repressor complexes (PRCs) are important chromatin modifiers fundamentally implicated in pluripotency and cancer. Polycomb silencing in embryonic stem cells (ESCs) can be accompanied by active chromatin and primed RNA polymerase II (RNAPII), but the relationship between PRCs and RNAPII remains unclear genome-wide. We mapped PRC repression markers and four RNAPII states in ESCs using ChIP-seq, and found that PRC targets exhibit a range of RNAPII variants. First, developmental PRC targ...

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APA Style

Brookes, E., de Santiago, I., Hebenstreit, D., Morris, K. J., Carroll, T., Xie, S. Q., Stock, J. K., Heidemann, M., Eick, D., Nozaki, N., Kimura, H., Ragoussis, J., Teichmann, S. A., & Pombo, A. (2012). Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs. Cell Stem Cell, 10(2), 157–170.

MLA Style

Brookes, E., et al. “Polycomb Associates Genome-Wide with a Specific RNA Polymerase II Variant, and Regulates Metabolic Genes in ESCs.” Cell Stem Cell, vol. 10, no. 2, 2012, pp. 157–70.

Chicago Style

Brookes, E, I de Santiago, D Hebenstreit, KJ Morris, T Carroll, SQ Xie, JK Stock, et al. 2012. “Polycomb Associates Genome-Wide with a Specific RNA Polymerase II Variant, and Regulates Metabolic Genes in ESCs.” Cell Stem Cell 10 (2): 157–70.
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