Journal article icon

Journal article

Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs.

Abstract:

Polycomb repressor complexes (PRCs) are important chromatin modifiers fundamentally implicated in pluripotency and cancer. Polycomb silencing in embryonic stem cells (ESCs) can be accompanied by active chromatin and primed RNA polymerase II (RNAPII), but the relationship between PRCs and RNAPII remains unclear genome-wide. We mapped PRC repression markers and four RNAPII states in ESCs using ChIP-seq, and found that PRC targets exhibit a range of RNAPII variants. First, developmental PRC targ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.stem.2011.12.017

Authors


Expand authors...
Journal:
Cell stem cell
Volume:
10
Issue:
2
Pages:
157-170
Publication date:
2012-02-05
DOI:
EISSN:
1875-9777
ISSN:
1934-5909
URN:
uuid:9ce4cca3-f749-4794-95f9-11b684e11ae2
Source identifiers:
254241
Local pid:
pubs:254241

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP