Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses.

Journal article

Effective HIV-specific T-cell immunity requires the ability to inhibit virus replication in the infected host, but the functional characteristics of cells able to mediate this effect are not well defined. Since Gag-specific CD8 T cells have repeatedly been associated with lower viremia, we examined the influence of Gag specificity on the ability of unstimulated CD8 T cells from chronically infected persons to inhibit virus replication in autologous CD4 T cells. Persons with broad (>or=6; n = 13) or narrow (

Authors: Julg, B; Williams, K; Reddy, S; Bishop, K; Qi, Y

• Publication status: Published
• Journal: Journal of virology
• Volume: 84
• Issue: 11
• Pages: 5540-5549
• Publication date: 2010-06-01
• DOI: 10.1128/jvi.02031-09
• EISSN: 1098-5514
• ISSN: 0022-538X
• Language: English
• Keywords: Virus Replication; Humans; gag Gene Products, Human Immunodeficiency Virus; HIV Infections; CD4-Positive T-Lymphocytes; T-Cell Antigen Receptor Specificity; CD8-Positive T-Lymphocytes; HIV-1; Cells, Cultured