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Oligomerisation of pneumolysin on cholesterol crystals: similarities to the behaviour of polyene antibiotics.

Abstract:
Pneumolysin is a cytolytic toxin of Streptococcus pneumoniae, a causative agent of pneumonia and meningitis. The prepore and pore states of pneumolysin have recently been investigated by cryo-electron microscopy and atomic force microscopy, confirming the existence of arc-shaped as well as ring-form oligomers. Here we provide further insights into the pneumolysin oligomer by studying the interaction of pneumolysin with cholesterol crystals, comparing the results to those obtained for polyene antibiotics, which also bind cholesterol.

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Authors


Sonnen, AF More by this author
Andrew, PW More by this author
Gilbert, RJ More by this author
Journal:
Toxicon : official journal of the International Society on Toxinology
Volume:
51
Issue:
8
Pages:
1554-1559
Publication date:
2008-06-05
DOI:
EISSN:
1879-3150
ISSN:
0041-0101
URN:
uuid:9cdf0d35-a6dd-42ff-bccc-640323da10f6
Source identifiers:
2052
Local pid:
pubs:2052

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