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Trapping or slowing the diffusion of T cell receptors at close contacts initiates T cell signaling

Abstract:

T cell activation is initiated by T cell receptor (TCR) phosphorylation. This requires the local depletion of large receptor-type phosphatases from “close contacts” formed when T cells interact with surfaces presenting agonistic TCR ligands, but exactly how the ligands potentiate signaling is unclear. It has been proposed that TCR ligands could enhance receptor phosphorylation and signaling just by holding TCRs in phosphatase-depleted close contacts, but this has not been directly tested. We ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.2024250118

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Role:
Author
ORCID:
0000-0001-5299-8368
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Role:
Author
ORCID:
0000-0003-3789-6421
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Role:
Author
ORCID:
0000-0002-8344-8016
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Role:
Author
ORCID:
0000-0002-0771-8491
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
118
Issue:
39
Article number:
e2024250118
Publication date:
2021-09-15
Acceptance date:
2021-08-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pmid:
34526387
Pubs id:
1197906
Local pid:
pubs:1197906

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