Journal article icon

Journal article

State-dependent mechanisms of LTP expression revealed by optical quantal analysis.

Abstract:
The expression mechanism of long-term potentiation (LTP) remains controversial. Here we combine electrophysiology and Ca(2+) imaging to examine the role of silent synapses in LTP expression. Induction of LTP fails to change p(r) at these synapses but instead mediates an unmasking process that is sensitive to the inhibition of postsynaptic membrane fusion. Once unmasked, however, further potentiation of formerly silent synapses leads to an increase in p(r). The state of the synapse thus determines how LTP is expressed.
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Expand authors...
Journal:
Neuron
Volume:
52
Issue:
4
Pages:
649-661
Publication date:
2006-11-05
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
URN:
uuid:9cd7aca1-0fbd-47f2-b430-5325200a5dcc
Source identifiers:
185134
Local pid:
pubs:185134

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP